Signalling pathways and gene expression profiles in prostate cancer

In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathways to progress through the uncontrolled proliferation of cancerous cells. Although the mechanisms of how the cells evade intrinsic or extrinsic signals of death and keep on dividing is not completely understood, there is a plethora of evidence that point to certain signalling molecules that are crucial conveyors of the fine tuning that slightly differs in cancer in comparison to control states. The present chapter provides a detailed description of the key regulators of PCa cell life and unveils their closely communicating proteins that aid in the fine tuning of the cancerous state

Pengaruh Kompensasi Dan Lingkungan Kerja Terhadap Kinerja Karyawan (Studi Kasus Pada Karyawan Hotel Patra Jasa Jakarta)

Labor or human resources have an important role in the company in order to achieve success.Therefore, companies must consider the factors that may affect the performance of employees, such ascompensation and working environment. Achievement of employee performance Patra Jasa Jakarta said notoptimal in which the employee\u27s performance increased in 2012 but decreased performance in 2013. The aim ofthis study was to determine how the compensation, working conditions, and the performance of employees inPatra Jasa Jakarta, as well as to determine the effect of compensation and work environment either partially orsimultaneously on the performance of employees in Patra Jasa Jakarta. This type of research is "explanatoryresearch". The sampling technique used is nonprobability sampling with saturated sampling method that usesall members of the population that all employees (non-led) 120 people. In proving the hypothesis test was usedcorrelation analysis, coefficient determination test, regression test (simple and multiple), and a significance test(t test and F test) with SPSS 16.0. The survey results revealed that the variable compensation (X1) and theWorking Environment variable (X2) partially and simultaneously positive and significant impact on employeeperformance variable (Y). Partially and simultaneously, variable compensation (X1) provide a strongerinfluence on employee performance variable (Y) than the Working Environment variable (X2). Suggestions canbe submitted is the company can evaluate and improve the elements that can affect the performance ofemployees, such as compensation and working environment where opportunities are promoted. and conditionsof hygiene and neatness in the space / workplace still considered good by the employees. The company can alsoprovide regular training and guiding employees so that the level of errors made in the work can be minimizedas possible

Implementing a Practice Doctorate Program at a Distance through an Urban-Rural Partnership

The purposes of this poster presentation are to 1) describe the implementation of a doctor of nursing practice (DNP) program by providing access to rigorous distance education to students living in rural Pennsylvania; 2) discuss building a critical mass of doctorally prepared advanced practice nurse experts in both urban and rural communities; and 3) share formative and summative evaluation information. Through funding from the U.S. Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Professions, Division of Nursing, the Jefferson School of Nursing (JSN) expanded its DNP program currently offered at the urban Philadelphia campus to the rural campus in Danville. Using the methodologies of live web-casting and live video over the Internet, distance students are afforded the opportunity to participate in a live classroom setting rather than experience the static distance methodology of reading through lectures themselves. For example, during the applied biostatistics course, the faculty teaches onsite in Philadelphia projecting the SPSS and the database on screen so that students on both campuses can simultaneously view, hear, and interact with the discussion. There is a doctorally prepared faculty member onsite in Danville as a resource for the students. These newer technologies make possible real-time faculty-student dialogue, student-to-student dialogue, and enhance socialization. Furthermore, the use of advanced technologies allows distance students to discuss with peers and faculty alike, in real time, the problems, successes, and questions which arise during class and clinical practica, thereby enhancing critical thinking and diagnostic reasoning skills. This unique urban-rural partnership, made possible through advanced technologies, addresses increasing demands for educating greater numbers of doctorally prepared advanced practice nurses to work in north and central rural Pennsylvania, thus promoting access to health care in rural underserved communities. Other than in academia, there are no doctorally prepared advanced practice nurses employed in practice in the area

Aktivitas Penghambatan Oksidasi Asam Linoleat Ekstrak Metanol Daun Soyogik (Saurauia bracteosa DC) dengan Metode Ferric Thiocyanate

Telah dilakukan penelitian untuk menentukan kandungan total fenolik dan aktivitas antioksidan ekstrak metanol daun soyogik (Saurauia bracteosa DC) sebagai peredam radikal bebas asam linoleat. Kandungan total fenolik diukur dengan metode Folin-Ciocalteu sedangkan aktivitas antioksidan diukur dengan metode FTC (Ferric Thiocyanate) untuk mengetahui kemampuan penghambatan peroksida pada tahap pertama oksidasi lipid.  Hasil penelitian menunjukkan bahwa ekstrak metanol memiliki kandungan total fenolik sebesar 99,67 mg/kg dan kemampuan dalam menghambat oksidasi asam linoleat sebesar 49,464%.This research has been conducted to measure the total phenolic compounds and the antioxidant activity of methanol extract of soyogik leaves (Saurauia bracteosa DC) as a reducer of free radicals linoleic acid. The total phenolic content was measured using folin-ciocalteu method, meanwhile the antioxidant activity was measured using FTC (Ferric Thiocyanate) method and to determine the peroxide inhibitory capability in the first stages of lipid peroxidation. The results showed that the methanol extract had a total phenolic content of 99, 67 mg/kg and peroxide inhibition of 49, 464

GAMBARAN AKTIVITAS FISIK MAHASISWA SEMESTER VI FAKULTAS KESEHATAN MASYARAKAT UNSRAT SAAT PEMBATASAN SOSIAL MASA PANDEMI COVID-19

Masalah gizi merupakan masalah kesehatan masyarakat. Kurang melakukan aktivitas fisik diidentifikasi menjadi penyebab tertinggi keempat terhadap mortalitas global. Aktivitas fisik merupakan segala bentuk pergerakan tubuh yang produktif oleh otot skeletal yang membutuhkan pengeluaran energi. Mahasiswa dalam menjalani kehidupan sehari-harinya tidak hanya terkait aktivitas perkuliahan saja. Berbagai aktivitas dapat dilakukan oleh mahasiswa dalam mengisi waktu luang dengan melakukan kegiatan ringan, sedang atau berat. Setiap kegiatan tersebut melibatkan kegiatan fisik. Tujuan penelitian untuk mengetahui gambaran aktivitas fisik mahasiswa FKM Unsrat semester VI saat pembatasan sosial masa pandemi COVID-19. Penelitian merupakan penelitian s urvei deskriptif, dilaksanakan pada bulan Juni sampai Oktober 2020 di Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado (via online). Sampel yang digunakan sebesar 161 mahasiswa. Instrumen penelitian: kuesioner menggunakan aplikasi google form, International Physical Activity Questionare/IPAQ (Short Last 7 Days). Pengolahan data menggunakan Analisis Univariat. Hasil penelitian pada Mahasiswa Semester VI Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi berdasarkan IPAQ paling banyak melakukan aktivitas fisik sedang yaitu sebesar 42,9%. Serta untuk tingkat aktivitas fisik berdasarkan recall aktivitas fisik 2 x 24 jam paling banyak responden melakukan aktivitas fisik ringan yaitu sebesar 79,3%. Kata Kunci : Aktivitas Fisik, Mahasiswa, COVID-19 ABSTRACTNutrition is a public health problem. Lack of physical activity was identified as the fourth highest cause of global mortality. Physical activity is any form of productive body movement by skeletal muscles that require energy expenditure. Students in living their daily lives are not only related to lecture activities. Various activities can be done by students in filling their free time by doing light, medium or sleen activities. Each of these activities involves physical activity. The purpose of the study was to describe of physical activity of students of FKM Unsrat semester VI during the COVID-19 pandemic social restrictions. The research is a descriptive survey research, conducted from June to October 2020 at the Faculty of Public Health, Sam Ratulangi University Manado (via online). The sample was 161 students. Research instrument: questionnaire using google form application, International Physical Activity Questionare/IPAQ (Short Last 7 Days). Data processing using Univariate Analysis. The results of the study in Semester 6 students of the Faculty of Public Health, Sam Ratulangi University based on IPAQ performed the most moderate physical activity of 42.9%. As well as for the level of physical activity based on the recall of physical activity 2 x 24 hours most respondents performed light physical activity of 79.3%. Keywords : Physical Activity, Student, COVID-1

Quantitative analysis of the 1981 and 2001 Etna flank eruptions: a contribution for future hazard evaluation and mitigation

Lava flows produced during Etna flank eruptions represent severe hazards for the nearby inhabited areas, which can be protected by adopting prompt mitigation actions, such as the building of diversion barriers. Lava diversion measures were attempted recently during the 1983, 1991-93, 2001 and 2002 Etna eruptions, although with different degrees of success. In addition to the complexity of barrier construction (due to the adverse physical conditions), the time available to successfully slow the advance of a lava flow depends on the lava effusion rate, which is not easily measurable. One method to estimate the average lava effusion rate over a specified period of time is based on a volumetric approach; i.e. the measurement of the volume changes of the lava flow over that period. Here, this has been compared to an approach based on thermal image processing, as applied to estimate the average effusion rates of lava flows during the 1981 and 2001 Etna eruptions. The final volumes were measured by the comparison of pre-eruption and post-eruption photogrammetric digital elevation models and orthophotographs. Lava volume growth during these eruptions was estimated by locating the flow-front positions from analyses of scientific papers and newspapers reports, as well as from helicopter photographs. The analyses of these two eruptions contribute to the understanding of the different eruptive mechanisms, highlighting the role of the peak effusion rate, which represents a critical parameter for planning of mitigation actions and for hazard evaluation

HUBUNGAN ANTARA PENGETAHUAN GIZI IBU DENGAN STATUS GIZI ANAK USIA 12-24 BULAN DI WILAYAH KERJA PUSKESMAS TATELI KECAMATAN MANDOLANG KABUPATEN MINAHASA

Permasalahan anak saat ini pada umumnya yaitu masalah kesulitan makan diantaranya kurangnya pengetahuan ibu mengenai gizi yang harus dipemuhi pada masa pertumbuhan anak. Tujuan dari penelitian ini untuk mengetahui apakah ada hubungan antara pengetahuan gizi ibu dengan status gizi anak usia 12- 24 bulan di Wilayah Kerja Puskesmas Tateli Kecamatan Mandolang Kabupaten Minahasa. Penelitian ini menggunakan Desain Penelitian Survey Analitik dengan pendekatan Cross Sectional, dilaksanakan pada bulan Juli-September 2019 di Wilayah Kerja Puskesmas Tateli Kecamatan Mandolang Kabupaten Minahasa. Sampel yang digunakan sebesar 70 anak. Instrumen penelitian: Kuesioner, timbangan berat badan dan microtoise. Pengolahan data menggunakan uji korelasi Spearman. Hasil uji statistik dalam penelitian menunjukkan status gizi dengan indikator BB/U gizi baik 68,6%, gizi kurang 28,6% dan gizi lebih 2,9%. Indikator TB/U tinggi 4,3%, normal 62,9%, pendek 30,0% dan sangat pendek 2,9%. Indikator BB/TB normal 70,0%, gemuk 86%, kurus 15,7% dan sangat kurus 5,7%. Sedangkan, Pengetahuan gizi ibu yang baik berjumlah 62,9%, cukup berjumlah 24,3% dan kurang 12,9%. Berdasarkan hasil uji Spearman menujukkan terdapat hubungan antara pengetahuan gizi ibu dengan (BB/U) nilai p =  0,006 tetapi tidak terdapat hubungan antara pengetahuan gizi ibu dengan (TB/U) nilai p = 0,244 dan (BB/TB) tidak terdapat hubungan dengan nilai p = 0,240  pada anak 12- 24 bulan di Wilayah Kerja Puskesmas Tateli Kecamatan Mandolang Kabupaten Minahasa. Kesimpulan diharapkan bagi ibu yang memiliki pengetahuan yang kurang baik untuk sering ke Posyandu saat kegiatan Posyandu berlangsung atau sudah dijadwalkan untuk mendapatkan penimbangan anak. Saran agar ibu juga mendapat penyuluhan dari petugas kesehatan agar dapat menambah pengetahuan agar dapat memenuhi kebutuhan nutrisisi anak. Kata Kunci: Pengetahuan Gizi Ibu dan Status Gizi ABSTRACTThe problem of children today in general is the problem of eating difficulties including lack of maternal knowledge about nutrition that must be met during the child's growing period. The purpose of this research was to determine whether there is a Relationship Between Mother's Nutrition Knowledge and The Nutritional Status of Children 12-24 Months In The Working Area of The Tateli Community Health Center, Mandolang District, Minahasa Regency. This research used an Analytical Survey research design with a Cross Sectional approach, carried out in July-September 2019 in the Tateli Community Health Center, Mandolang District, Minahasa Regency. The sample used was 70 children. Research instruments: Questionnaires, Weight Scales and Microtoise. Data processing using the Spearman Correlation test. The results of statistical tests in the research indicate that the nutritional status with an indicator of Body Weight/Age is 68.6% good nutrition, 28.6% malnutrition and 2.9% over nutrition. Indicator Height/Age, high 4.3%, normal 62.9%, short 30.0% and very short 2.9%. Indicator of Body Weight/Height is 70.0% normal, 86% fat, 15.7% thin and very thin 5.7%. Meanwhile, good knowledge of maternal nutrition is amount 62.9%, enough amounted to 24.3% and less 12.9%. Based on the results of the Spearman test shows there is a relationship between maternal nutrition knowledge with (BB/U) p value = 0,006 but there is no relationship between maternal nutritional knowledge with (TB/U) p value = 0,244 and (BB/TB) value of p = 0,240 in children 12-24 months in the working are of the Tateli Community Health Center, Mandolang District, Minahasa Regency. It is expected that mothers who have inadequate knowledge often go to integrated healthcare post when they doing activities take place or have been scheduled to get a child's weighing. So that mothers also receive counseling from health workers in order to increase knowledge in order to meet the nutritional needs of children. Keywords: Mother’s Nutritional Knowledge and Nutritional Statu

GAMBARAN KECUKUPAN VITAMIN LARUT AIR PADA MAHASISWA SEMESTER VI DI FAKULTAS KESEHATAN MASYARAKAT UNIVERSITAS SAM RATULANGI MANADO SELAMA MASA PANDEMI COVID-19

Vitamin merupakan senyawa yang diperlukan tubuh dalam jumlah yang sedikit untuk proses metabolisme. Menurut kelarutannya, vitamin terbagi menjadi vitamin larut lemak dan vitamin larut air. Vitamin larut air antara lain vitamin B kompleks dan vitamin C. Mengonsumsi vitamin yang cukup merupakan salah satu cara untuk mempertahankan kesehatan di tengah pandemi Covid-19 yang terjadi saat ini. Tujuan penelitian ini yaitu untuk mengetahui gambaran kecukupan vitamin larut air pada mahasiswa semester VI di Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado selama masa pandemi Covid-19. Penelitian ini merupakan penelitian kuantitatif dengan survei deskriptif yang dilaksanakan di Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado pada bulan Mei-November 2020 dengan jumlah sampel sebanyak 128 responden. Instrumen penelitian yang digunakan yaitu Formulir Food Record untuk mendapatkan data asupan makanan dari responden selama 2 hari. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki asupan vitamin B1 yang kurang yaitu 86,7% dan responden dengan asupan vitamin B1 yang cukup yaitu 13,3%. Dari hasil penelitian ini juga diketahui responden yang memiliki asupan vitamin B2 yang kurang yaitu 82,8% dan responden dengan asupan vitamin B2 yang cukup yaitu 17,2%. Untuk asupan vitamin B6 diperoleh bahwa sebagian besar responden memiliki asupan vitamin B6 yang kurang yaitu 69,5% dan responden dengan asupan vitamin B6 yang cukup yaitu 30,5%. Adapun responden yang memiliki asupan vitamin C yang kurang yaitu 93,8% dan responden dengan asupan vitamin C yang cukup yaitu 6,3%. Kata Kunci: Kecukupan Vitamin Larut Air, Mahasiswa, Covid-19 ABSTRACTVitamins are compounds that the body needs in small amounts for metabolic processes. According to its solubility, vitamins are divided into fat-soluble vitamins and water soluble vitamins. Water soluble vitamins include vitamin B complex and vitamin C. Consuming adequate vitamins is one way to maintain health amid the current Covid-19 outbreak. The purpose of this study was to determine the adequacy of water soluble vitamins in semester VI students at the Faculty of Public Health of Sam Ratulangi University Manado during the Covid-19 pandemic. This research is a quantitative study with a descriptive survey conducted at the Faculty of Public Health of Sam Ratulangi University Manado in May-November 2020 with a total sample of 128 respondents. The research instrument used was the Food Record Form to obtain food intake data from respondents for 2 days. The results showed that the most of the respondents had less vitamin B1 intake, namely 86.7% and respondents with sufficient vitamin B1 intake namely 13.3%. From the results of this study, it was also known that respondents who had less vitamin B2 intake were 82.8% and respondents who had sufficient vitamin B2 intake were 17.2%. For the intake of vitamin B6, it was found that most of the respondents had insufficient intake of vitamin B6, namely 69.5% and respondents with sufficient intake of vitamin B6 namely 30.5%. Respondents who had insufficient vitamin C intake were 93.8% and respondents with sufficient vitamin C intake were 6.3%. Keywords: Adequacy of Water Soluble Vitamins, Students, Covid-1

Gambaran Pengetahuan, Sikap, dan Praktik Gizi Seimbang Remaja di Jemaat GMIM Kalvari Kombos Timur

Peran penting yang sangat memengaruhi derajat kesehatan masyarakat adalah gizi. Kondisi gizi dari seseorang dipengaruhi beberapa faktor yaitu pengetahuan, sikap, dan praktik terkait gizi seimbang. Penerapan terkait gizi seimbang masih kurang dilakukan salah satunya karena penyampaian informasi yang tidak maksimal. Tujuan dari penelitian ini ialah untuk mengetahui gambaran pengetahuan, sikap, dan praktik gizi seimbang dari remaja di jemaat GMIM Kalvari Kombos Timur. Penelitian ini menggunakan survei deskriptif dengan sampel penelitian adalah seluruh anggota remaja GMIM Kalvari Kombos Timur dan menggunakan data primer atau data yang didapatkan langsung dari lapangan serta data sekunder mendukung gambaran umum wilayah. Penelitian ini menggunakan analisis univariat. Hasil dari penelitian menunjukkan bahwa mayoritas responden yaitu 72,5% memiliki pengetahuan baik, 97,8% memiliki sikap baik, dan 73,6% memiliki praktik baik terhadap gizi seimbang.  Kata Kunci: Pengetahuan, Sikap, Praktik ABSTRACTAn important aspect that significantly affects the degree of public health is nutrition. The nutritional condition of a person is influenced by several factors, namely knowledge, attitudes, and practices related to balanced nutrition. Applications related to balanced nutrition are still lacking, one of which is because the delivery of information is not optimal. The purpose of this study is to describe the knowledge, attitudes, and practices of balanced nutrition among the adolescents in the GMIM Kalvari Kombos Timur congregation. This study uses a descriptive survey with the research sample being all members of the GMIM Kalvari Timur Kombos adolescents and using primary data or data obtained directly and secondary data to support the general description of the area. This study used univariate analysis. The results of the study showed that the majority of respondents which is 72.5% have good knowledge, 97.8% have good attitudes, and 73.6% have good practices towards balanced nutrition.  Keywords: Knowledge, Attitudes, Practices